6533b82bfe1ef96bd128cd88
RESEARCH PRODUCT
Cellular and Molecular Heterogeneity Associated with Vessel Formation Processes
Hedden RanfleyAlan Sales BarbosaJousie Michel PereiraPollyana Ribeiro CastroCarlos Alberto GonçalvesMariane FelipettoBárbara Betônico BergLucíola S. BarcelosIsabela Ribeiro Paivasubject
0301 basic medicineAngiogenesisNeovascularization Physiologiclcsh:MedicineReview ArticleBiologyMolecular heterogeneityGeneral Biochemistry Genetics and Molecular BiologyMural cell03 medical and health sciences0302 clinical medicineVasculogenesisAnimalsHumansGeneral Immunology and Microbiologylcsh:RVascular biologyGeneral MedicineLymphangiogenesis030104 developmental biologyOrgan Specificity030220 oncology & carcinogenesisBlood VesselsArteriogenesisNeuroscienceSignal Transductiondescription
The microvasculature heterogeneity is a complex subject in vascular biology. The difficulty of building a dynamic and interactive view among the microenvironments, the cellular and molecular heterogeneities, and the basic aspects of the vessel formation processes make the available knowledge largely fragmented. The neovascularisation processes, termed vasculogenesis, angiogenesis, arteriogenesis, and lymphangiogenesis, are important to the formation and proper functioning of organs and tissues both in the embryo and the postnatal period. These processes are intrinsically related to microvascular cells, such as endothelial and mural cells. These cells are able to adjust their activities in response to the metabolic and physiological requirements of the tissues, by displaying a broad plasticity that results in a significant cellular and molecular heterogeneity. In this review, we intend to approach the microvasculature heterogeneity in an integrated view considering the diversity of neovascularisation processes and the cellular and molecular heterogeneity that contribute to microcirculatory homeostasis. For that, we will cover their interactions in the different blood-organ barriers and discuss how they cooperate in an integrated regulatory network that is controlled by specific molecular signatures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-10-01 | BioMed Research International |