6533b82bfe1ef96bd128d18e

RESEARCH PRODUCT

Influence of Drawing on the Antimicrobial and Physical Properties of Chlorhexidine-Compounded Poly(caprolactone) Monofilaments

Roberto ScaffaroLuigi BottaGiuseppe GalloAnna Maria Puglia

subject

Materials Chemistry2506 Metals and AlloyPolymers and Plasticchlorhexidinedrug deliveryOrganic Chemistrymechanical propertiemelt processingChemical Engineering (all)antimicrobial filament

description

In this work, we prepared poly(caprolactone) (PCL) monofilaments incorporating different amounts of the antiseptic chlorhexidine diacetate (CHX) and evaluated the effect of "online" drawing during the melt spinning or of an "offline" cold drawing on the antimicrobial and physical properties of PCL/CHX monofilaments. The results showed that the drawing conditions strongly affected the properties of the threads. In particular, the filaments exhibited antimicrobial activity for all the draw ratios (DR) adopted, but on increasing DR the antibacterial efficiency reduced. These results were correlated with the CHX surface concentration and with the release kinetics.

yearjournalcountryeditionlanguage
2015-01-01
10.1002/mame.201500121http://hdl.handle.net/10447/202026