ChemInform Abstract: Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I.

6533b82bfe1ef96bd128d4b1

RESEARCH PRODUCT

ChemInform Abstract: Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I.

Nadia Chahboune M. Carmen Zafra-polo Olga ÁLvarez Colom Alicia Bardón Adriana Neske

subject

Inhibitory potency chemistry.chemical_compound biology Chemistry Stereochemistry Acetogenin Gigantetronenin General Medicine biology.organism_classification Tucupentol Mitochondrial Complex I Annona montana

description

Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.

year	journal	country	edition	language
2009-07-28	ChemInform

https://doi.org/10.1002/chin.200930217

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