6533b82bfe1ef96bd128d7f6

RESEARCH PRODUCT

Asymmetric Oxidative Mannich Reactions

Jaume Rostoll-berenguerJosé R. PedroCarlos VilaGonzalo Blay

subject

CatàlisiChemistryReacció d'oxidació-reduccióEnantioselective synthesisOrganic chemistryGeneral ChemistryOxidative phosphorylationAminesMannich reaction

description

The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have been reported using amines as electrophiles. This review provides an overview of these recent publications, including the different oxidants used and the scope and limitations of the different catalytic systems.

yearjournalcountryeditionlanguage
2020-11-09
10.1002/adsc.202001017https://hdl.handle.net/10550/84627