6533b82bfe1ef96bd128debe
RESEARCH PRODUCT
IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1
Francesco Carinisubject
Crohn’s diseaselcsh:R5-920TIM-3/galectin-9.TIM-3/galectin-9Inflammatory Bowel Diseaseslcsh:Medicine (General)description
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic and environmental factors. The interaction of these factors causes an imbalance in the microbiota, leading to the activation of several immunological and inflammatory mechanisms. From an immunological point of view, there seems to be an involvement of the TIM-3/galectin-9 pathway and of the autoregulation of LyTh1. The studies show that in patients with CD the autoregulation of LyTh1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reasons for the state of perpetual activation in LyTh1, resulting in the chronic inflammatory process.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-05-01 | Euromediterranean Biomedical Journal |