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RESEARCH PRODUCT
Density functional theory study of the 5-pyrrolidin-2-yltetrazole-catalyzed aldol reaction
Ramón J. ZaragozáManuel ArnóLuis R. Domingosubject
chemistry.chemical_classificationStereochemistryCarboxylic acidOrganic ChemistryCatalysisCatalysisEnamineInorganic Chemistrychemistry.chemical_compoundchemistryAldol reactionComputational chemistryAcetoneReactivity (chemistry)Density functional theoryStereoselectivityPhysical and Theoretical Chemistrydescription
Abstract The replacement of the carboxylic acid functionality with a tetrazolic acid in the proline-catalyzed asymmetric aldol reaction between acetone and trimethylacetaldehyde has been studied using DFT methods at the B3LYP/6-31G** computational level. For the C–C bond-formation step, four reactive channels corresponding to the syn and anti arrangement of the enamine and the re and si attack modes have been analyzed. The B3LYP/6-31G** results allowed us to explain the stereoselectivity and the increase in reactivity relative to the proline-catalyzed process in DMSO.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-08-01 | Tetrahedron: Asymmetry |