6533b82bfe1ef96bd128e0d7
RESEARCH PRODUCT
(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.
Heinz C. SchröderWolfgang PfleidererRobert J. SuhadolnikRamamurthy CharubalaWerner E.g. Müllersubject
OligoribonucleotidesbiologyRNase P2'-5'-OligoadenylateAdenine NucleotidesHIVbiology.organism_classificationVirus ReplicationBiochemistryVirologyMolecular biologyAntiviral AgentsVirusRetrovirusBiochemistryImmunityComplementary DNAbiology.protein2'5'-Oligoadenylate SynthetaseReverse Transcriptase InhibitorsRibonuclease LIntracellularHIV Long Terminal RepeatRetroviridae Infectionsdescription
1. 1. The double-stranded RNA-dependent 2′,5′-oligoadenylate (2–5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. 2. Until recently, the application of 2–5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. 3. Two new strategies have been developed which yield a selective antiviral effect of 2–5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an “intracellular immunization” appproach using 2-5A synthetase cDNA linked to HIV trans -acting response element (TAR) and (ii) inhibition of retroviral reverse transcriptase activity by 2-5A analogues.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | The International journal of biochemistry |