6533b82bfe1ef96bd128e279

RESEARCH PRODUCT

Antigen-processing machinery breakdown and tumor growth.

Markus MaeurerSoldano FerroneBarbara Seliger

subject

MHC class IIAntigen PresentationProteasome Endopeptidase ComplexbiologyAntigen processingImmunologyAntigen presentationHistocompatibility Antigens Class IHistocompatibility Antigens Class IIATP-binding cassette transporterMajor histocompatibility complexIn vitroMalignant transformationCysteine EndopeptidasesATP Binding Cassette Transporter Subfamily B Member 3Multienzyme ComplexesNeoplasmsMHC class IImmunologybiology.proteinCancer researchAnimalsHumansATP-Binding Cassette Transporters

description

Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.

yearjournalcountryeditionlanguage
2000-08-23Immunology today
10.1016/s0167-5699(00)01692-3https://pubmed.ncbi.nlm.nih.gov/10953098