6533b82cfe1ef96bd128ed7e
RESEARCH PRODUCT
Development and pathology of echinostoma caproni in experimentally infected mice
Javier SotilloCarla Muñoz-antoliCarlos MonteagudoBernard FriedBernard FriedAntonio MarcillaRafael Toledosubject
MaleNeutrophilsRatónEchinostoma caproni:CIENCIAS DE LA VIDA [UNESCO]Host-Parasite InteractionsEchinostomatidaeMiceRandom AllocationUNESCO::CIENCIAS DE LA VIDAAnimalsParasite hostinginfected miceMesenteryIntestinal MucosaechinostomaEcology Evolution Behavior and SystematicsAnalysis of VarianceEchinostomiasisMice Inbred ICRcaproniBiomphalariabiologyHost (biology):CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animal [UNESCO]biology.organism_classificationIntestinesUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animalImmunologyLeukocytes MononuclearParasitologyGoblet CellsTrematodaEchinostomadescription
In the present article, several parasitological features of mice, each experimentally infected with 75 metacercariae of Echinostoma caproni (Trematoda: Echinostomatidae), were studied during the first 12 wk postinfection. Moreover, the early pathological responses also were analyzed and compared with data previously published on other host species of E. caproni to gain further insight into the factors determining worm rejection or establishment of chronic infections. The results obtained show that the pattern of E. caproni infection in mice is consistent with a highly compatible host–parasite system. This combination is characterized by a high worm establishment, high egg output, and long survival of the worms. However, some differences with respect to other highly compatible hosts have been observed, particularly in relation to the survival of the adult worms. Histological studies suggest that the kinetics of goblet cells, mucosal neutrophils, and mononuclear inflammatory cells in the mesentery seem to be essential in determining the course of E. caproni infection in mice. Sotillo Gallego, Javier, Javier.Sotillo@uv.es ; Monteagudo Castro, Jose Carlos, Carlos.Monteagudo@uv.es ; Marcilla Diaz, Antonio, Antonio.Marcilla@uv.es
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-01-01 |