6533b82cfe1ef96bd128f2ba

RESEARCH PRODUCT

Development of phylogroup-specific taqman real-time assays for identification of members of klebsiella pneumoniae complex

subject

description

International audience; • Klebsiella Klebsiellapneumoniae pneumoniae pneumoniae (Kp )represents agrowinggrowing public publichealth concern due to the emergence emergence of multidrug multidrug multidrug resistance resistance and andhypervirulence hypervirulence . • The Kp species complex complex includes includes 7closely related related phylogroups :Klebsiella Klebsiellapneumoniae (phylogroup (phylogroup Kp 1), K.quasipneumoniae quasipneumoniae quasipneumoniae subsp .quasipneumoniae quasipneumoniae (Kp 2)and subsp .similipneumoniae similipneumoniae similipneumoniae similipneumoniae similipneumoniae (Kp 4), K.variicola variicola subsp .variicola variicola variicola(Kp 3)and subsp .tropicalensis (Kp 5), ‘K.quasivariicola quasivariicola ’ (Kp 6)and K.africanensis africanensis (Kp 7). • Routine Routinemethods methods are not suitable suitable for phylogroup phylogroup phylogroup identification identification identification and often leadlead to misidentification misidentification misidentification misidentification .Reliable Reliable identification identification identification identification is currently currently based basedon specific specific genetic markers or genome sequencing sequencing .