6533b82cfe1ef96bd128f427
RESEARCH PRODUCT
Chemical constituents from Anthocleista liebrechtsiana De Wild & T. Durand (Loganiaceae)
Roland T. TchuenguemBeaudelaire Kemvoufo PonouFrancis T. NgouafongJean Paul DzoyemRémy Bertrand TeponnoLéon Azefack TapondjouTill OpatzJonas Kühlbornsubject
biologyAcacetin010405 organic chemistryStereochemistryAnthocleistaLoganiaceaebiology.organism_classificationAntimicrobial01 natural sciencesBiochemistry0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryBetulinic acidOleanolic acidEcology Evolution Behavior and SystematicsDerivative (chemistry)Lupeoldescription
Abstract A new steroid derivative, (24S)-3β-hydroxy-7β-methoxyergost-5-ene (1), was isolated along with eleven known compounds: 7α-hydroxysterol (2), β-sitosterol (3), oleanolic acid (4), betulinic acid (5), lupeol (6), swertiaperennin (7), decussatin (8), tetracosanoic acid (9) β-sitosterol-3-O-β- d -glucopyranoside (10), (2R,3S)-2,3-dihydro-2-(3,4-dimethoxyphenyl)-3-hydroxymethyl-5-(2-formylvinyl)-7-hydroxybenzofuran (11) and acacetin 6-C-β- d -glucopyranoside (12) from the tree bark and leaves of Anthocleista liebrechtsiana De Wild & T. Durand. Their structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and mass spectrometric data. Compounds 2 and 7–10 have already been isolated from the genus Anthocleista and 3–6 from the Loganiaceae family. The isolated secondary metabolites were screened for their antimicrobial properties but only compound 12 showed moderate activity against Pseudomonas aeruginosa. Furthermore, the chemotaxonomic significance among Anthocleista species is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | Biochemical Systematics and Ecology |