6533b82cfe1ef96bd128f554
RESEARCH PRODUCT
Synthesis of methyl derivatives of linear and angular thienocoumarins and thiopyranocoumarins
Paolo RodighieroA. MarottoAdriana ChilinGiovanni Pastorinisubject
chemistry.chemical_compoundChemistryComputational chemistryOrganic Chemistrypsoralen analogs; DNA; photoreagentsPropargyl chlorideOrder (group theory)DNApsoralen analogsphotoreagentsdescription
New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7-mercaptocoumarin, which were condensed with chloro-ketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine which methods produced the best yields of the desired thienocoumarins 15, 16, 17, 18, 22, 23, 24, 27 and thiopyranocoumarins 28 and 29.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-07-01 |