6533b82cfe1ef96bd128f78e

RESEARCH PRODUCT

Dipeptidyl Peptidase IV as a Muscle Myokine

Heidi A. Kluess

subject

0301 basic medicinemedicine.medical_specialtyanimal structuresPhysiologymuscleMini ReviewNeuropeptideIncretin030204 cardiovascular system & hematologyDipeptidyl peptidaselcsh:Physiology03 medical and health sciences0302 clinical medicinePhysiology (medical)Internal medicineMyokinemedicinemetalloproteasesSerine proteaseMetalloproteinasebiologyexerciselcsh:QP1-981ChemistrySkeletal musclewhey proteinpeptidasesecretome030104 developmental biologyEndocrinologymedicine.anatomical_structurebiology.proteinHormone

description

Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work suggests that skeletal muscle releases DPP-IV as a myokine and participates in control of muscle blood flow. However, few of the functions of DPP-IV as a myokine have been investigated to date and there is a poor understanding about what causes DPP-IV to be released from muscle.

yearjournalcountryeditionlanguage
2020-03-01Frontiers in Physiology
10.3389/fphys.2020.00148https://www.frontiersin.org/article/10.3389/fphys.2020.00148/full