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RESEARCH PRODUCT

From tryptophan metabolism to peptide antibiotic production in Streptomyces coelicolor

Anna GiardinaAnna Maria PugliaS MarineoF Zummo

subject

Streptomyces coelicolor correlation between tryptophan metabolism and antibiotic production

description

The tryptophan is a precursor of the lipopeptide calcium dependent antibiotic (CDA), produced from Streptomyces coelicolor and closely related to important antibiotics such as daptomycin. We have focused our attention on the correlation between CDA production and tryptophan metabolism in order to identify new strategies aimed at increasing the production of peptide antibiotics.

http://hdl.handle.net/10447/58621