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RESEARCH PRODUCT
Distribution and Dynamics of Transcription-Associated Proteins during Parvovirus Infection
Einari A. NiskanenEinari A. NiskanenOuti PaloheimoHanna SmolanderHanna SmolanderMaija Vihinen-rantaMinna U. KaikkonenJuha P. LaurilaJuha P. LaurilaSami F. WillmanTeemu O. Ihalainensubject
Parvovirus CanineViral nonstructural proteinvirusesImmunologyMicrobiologyParvoviridae Infections03 medical and health sciencesVirologyAnimalsTranscription factor030304 developmental biology0303 health sciencesbiologyParvovirusBinding protein030302 biochemistry & molecular biologyCanine parvovirusFluorescence recovery after photobleachingbiology.organism_classificationMolecular biology3. Good healthVirus-Cell InteractionsCell CompartmentationInsect Sciencebiology.proteinTATA-binding proteinTranscription factor II BSubcellular FractionsTranscription Factorsdescription
ABSTRACT Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-12-15 |