6533b82cfe1ef96bd129014f
RESEARCH PRODUCT
Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial.
Alessandra CasuccioPatrizia VillariVincenza Manuela SpedaleFabrizio DavidSebastiano Mercadantesubject
medicine.medical_specialtyPostoperative painmedicine.medical_treatmentOpioidPostoperative pain03 medical and health sciences0302 clinical medicineBolus (medicine)030202 anesthesiologyNeoplasmsMedicineHumans030212 general & internal medicineAdverse effectGynecological surgeryPain MeasurementPain PostoperativeMorphinebusiness.industryGynecological cancerSurgeryClinical trialAnalgesics OpioidAnesthesiology and Pain MedicineAnesthesiaGynecological cancerMorphineFemalebusinessMethadoneMethadonemedicine.drugdescription
Abstract Study objective The aim of this study was to compare methadone and morphine for the management of postoperative. Design Open, controlled study. Setting Postoperative recovering area, ward. Patients Sixty-four patients, ASA I-III, undergoing gynecological surgery for cancer. Interventions Morphine or methadone 0.15 mg/kg given preoperatively. After operation an intravenous morphine or intravenous methadone infusion at doses of 12 mg/day was started. Measurements Pain intensity and opioid consumption. Main results Methadone infusion provided a better analgesia in comparison with morphine infusion on the second day. Opioid consumption was significantly lower in the methadone group. No episodes of relevant desaturation or signs of respiratory depression were recorded. Conclusion A preoperative bolus of methadone, followed by a continuous infusion of low doses post-operatively, provided a better analgesia, without adding risk of adverse effects, in comparison with morphine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-05-01 | Journal of clinical anesthesia |