UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function.

6533b82cfe1ef96bd1290166

RESEARCH PRODUCT

UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function.

Yves Artur Jean-marie Heydel Nicolas Thiebaud Arièle Legendre Elzbieta J. Holsztynska Anne-marie Le Bon

subject

Olfactory system MESH : RNA Messenger [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition MESH: Glucuronosyltransferase MESH : Blood-Brain Barrier MESH: Blood-Brain Barrier chemistry.chemical_compound 0302 clinical medicine MESH: Smell Pharmacology (medical)MESH: Animals MESH: Uridine Diphosphate MESH: Nerve Tissue Proteins Glucuronosyltransferase General Pharmacology Toxicology and Pharmaceutics MESH : Olfactory Bulb MESH : Nerve Tissue Proteins 0303 health sciences MESH: Gene Expression Regulation Enzymologic Olfactory Pathways Olfactory Bulb MESH : Odors Cell biology Smell medicine.anatomical_structure Blood-Brain Barrier MESH: Olfactory Bulb medicine.medical_specialty Central nervous system Nerve Tissue Proteins In situ hybridization Olfaction Biology digestive system Gene Expression Regulation Enzymologic Olfactory Receptor Neurons Uridine Diphosphate MESH : Gene Expression Regulation Enzymologic 03 medical and health sciences Internal medicine medicine Animals RNA Messenger MESH : Uridine Diphosphate 030304 developmental biology MESH: RNA Messenger MESH: Odors MESH : Olfactory Pathways MESH : Glucuronosyltransferase MESH: Olfactory Receptor Neurons Olfactory bulb Uridine diphosphate Endocrinology chemistry Odorants MESH : Smell MESH : Olfactory Receptor Neurons MESH : Animals Olfactory epithelium [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery Function (biology)MESH: Olfactory Pathways

description

International audience; This work aims to review uridine diphosphate (UDP)-glucuronosyltransferase (UGT) expression and activities along different neuronal structures involved in the common physiological process of olfaction: olfactory epithelium, olfactory bulb, and olfactory cortex. For the first time, using high-throughput in situ hybridization data generated by the Allen Brain Atlas (ABA), we present quantitative analysis of spatial distribution of UGT genes in the mouse brain. The olfactory area is a central nervous system site with the highest expression of UGTs, including UGT isoforms not previously identified in the brain. Since there is evidence of the transfer of xenobiotics to the brain through the nasal pathway, circumventing the blood-brain barrier, olfactory UGTs doubtlessly share the common function of detoxification, but they are also involved in the metabolism and turnover of exogenous or endogenous compounds critical for physiological olfactory processing in these tissues. The function of olfactory UGTs will be discussed with a special focus on their participation in the perireceptor events involved in the modulation of olfactory perception.

year	journal	country	edition	language
2010-02-01

10.3109/03602530903208363 https://hal.archives-ouvertes.fr/hal-00745697