Purīna patēriņš maizes rauga Saccharomyces cerevisiae purīna sintēzes mutantos

6533b82cfe1ef96bd12903c2

RESEARCH PRODUCT

Purīna patēriņš maizes rauga Saccharomyces cerevisiae purīna sintēzes mutantos

Jana Kassaliete

subject

iekššūnu rezerves adenīns hipoksantīns Bioloģija purīnu patēriņš Auksotrofija

description

Maizes raugs ir lielisks eikariotu metabolisma pētījuma objekts, kas var stipri uzlabot izpratni par purīna metabolismu, un tā iespējamiem praktiskiem pielietojumiem. Šī darba ietvaros purīna biosintēzes de novo metaboliskā ceļa mutanti tika audzēti purīna limitācijas apstākļos 96 lauciņu platē. Iegūtās augšanas līknes tika analizētas, lai iegūtu informāciju par periodisko kultūru kinētiskiem parametriem, substrātu afinitāti un purīnu iekššūnas rezervēm. Tika noskaidrots, ka adenīna auksotrofiem ir lielāka afinitāte pret āršūnas adenīnu, salīdzinot ar hipoksantīnu. Āršūnu hipoksantīns ir pārsvarā izmantots purīnu rezervju veidošanā, kas bija lielākas CEN.PK celmā. Purīna biosintēzes ceļa sākuma posma mutanti patērēja purīnu efektīvāk, kas varētu norādīt uz to lomu metabolisma ceļa regulācijā.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/50715

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