Vaccinum ģints ogu spiedpalieku ekstraktu efekti uz alfa glikozidāzes aktivitāti

6533b82cfe1ef96bd1290433

RESEARCH PRODUCT

Vaccinum ģints ogu spiedpalieku ekstraktu efekti uz alfa glikozidāzes aktivitāti

subject

Vaccinium spp. ogu ekstrakti Farmācija IC50 alfa-glikozidāzes inhibitori inhibīcija

description

Alfa-glikozidāzes inhibitori ir orāli pretdiabēta līdzekļi, ko lieto 2. tipa cukura diabēta ārstēšanai, lai novērstu vai palēninātu ogļhidrātu (piemēram, cietes un cukura) gremošanu. Arī starp dabas vielām tiek meklēti alfa-glikozidāzes inhibitori. Darba mērķis: pētīt melleņu, krūmmelleņu, lielogu dzērveņu, dzērveņu un brūkleņu ogu spiedatlieku ekstraktu ietekmi uz alfa glikozidāzes aktivitāti in vitro. Pētījumā ogu sauso ekstraktu aktivitāte ir pētīta ūdens un metanola ekstraktu šķīdumiem. Rezultāti liecina, ka visiem šo ogu ekstraktiem ir alfa glikozidāzes inhibēšanas spēja, bet ekstraktu šķīdumiem ūdenī tā ir gandrīz 10 reizes vājāka kā metanola. No ekstraktu šķīdumiem metanolā vislielākā alfa glikozidāzes inhibēšanas spēju uzrāda brūkleņu ekstrakts ar IC50 0,00016 mg/ml koncentrācijā. Secinām, ka ogas ir ieteicamas cukura diabēta pacientiem lietošanai uzturā.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/39220

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