6533b82dfe1ef96bd1290802

RESEARCH PRODUCT

Selectively Functionalized Constrained Polyazamacrocycles: Building Blocks for Multifunctional Chelating Agents

Marie-josé PenouilhFranck DenatClaire BernhardYoann RousselinPauline DésogèreChristine Goze

subject

chemistry.chemical_compoundChemistryOrganic ChemistryCarbon skeletonRegioselectivityOrganic chemistryChelationPhysical and Theoretical ChemistryBifunctionalCombinatorial chemistry

description

A new class of cross-bridged and side-bridged 1,4,7,10-tetraazacyclotridecanes (homocyclens) bearing an aminomethyl pendant arm on the carbon skeleton has been prepared. The regioselectivity of the quaternization of the bis-aminal intermediates is discussed on the basis of X-ray diffraction and NMR experiments. These new polyazamacrocycles are valuable precursors of bifunctional chelating agents for applications in nuclear medicine.

yearjournalcountryeditionlanguage
2013-01-25European Journal of Organic Chemistry
https://doi.org/10.1002/ejoc.201201337