6533b82dfe1ef96bd129081e
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Pyrido(2,3-d)pyrimidines in the Reaction of 6-Amino-2,3- dihydro-2-thioxo-4(1H)-pyrimidinone with Chalcones.
A. SanchezHerbert MeierManuel NoguerasJairo QuirogaBraulio Insuastysubject
chemistry.chemical_compoundPyrimidinechemistryStereochemistryGeneral MedicineSpectroscopydescription
6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone (1) reacts in boiling DMF with α,/β-unsaturated ketones 2 yielding the pyrido[2,3-d]pyrimidine systems 5 and 6, respectively. The orientation in the addition process can be determined by nmr measurements, especially by NOE difference spectroscopy. The products do not correspond to a normal Skraup or Doebner-v. Miller synthesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-21 | ChemInform |