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RESEARCH PRODUCT
Addition of organolithium reagents to cinnamic acids
Elena MuñozRamon MestresMaría José AurellMaría-josé Bañulssubject
chemistry.chemical_compoundchemistryReagentOrganic ChemistryDrug DiscoverySubstituentButyllithiumElectronic effectOrganic chemistryComposition (visual arts)Biochemistrydescription
Abstract Reaction of tert -butyllithium with p - and m -substituted cinnamic acids at low temperature affords mixtures of 1,4- and 1,3-addition products, whose composition depend on the nature of the substituents. Electron-donating and electron-withdrawing groups favour 1,4- and 1,3-additions, respectively. Linear correlations are obtained with electronic effect and with radical substituent constants.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-01 | Tetrahedron |