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RESEARCH PRODUCT
A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1)
Karl-hermann Meyer Zum BüschenfeldeMalte PetersStefan Rose JohnDiane PennicaElke Roebsubject
medicine.medical_specialtyCarcinoma HepatocellularCardiotrophin 1medicine.medical_treatmentBiophysicsGene ExpressionCiliary neurotrophic factorBiochemistryCardiotrophin 1Structural BiologyInternal medicineGene expressionGeneticsmedicineTumor Cells CulturedAnimalsHumansHepatocyteInterleukin 6Molecular BiologybiologyInterleukin-6Acute-phase proteinCell BiologyMolecular biologyMacroglobulinRatsmedicine.anatomical_structureEndocrinologyCytokineHepatocytebiology.proteinCytokinesInterleukin-6-cytokine familyAcute-Phase ProteinsAcute-phase responsedescription
Abstract Recently, a novel cytokine, cardiotrophin-1 (CT-1), was cloned and found to induce cardiac myocyte hypertrophy in vitro. Amino acid sequence similarity showed CT-1 to be a member of the IL-6/LIF/CNTF/OSM/IL-11 cytokine family. Since all known members of the IL-6 cytokine family induce an hepatic acute phase protein (APP) gene expression, we investigated the ability of CT-1 to induce a liver acute phase response. Upon stimulation of rat hepatoma cells, CT-1 and LIF induced the strongest rat fibrinogen mRNA expression, OSM and IL-6 induced a less pronounced response. When human hepatoma cells and primary rat hepatocytes were stimulated with CT-1, the expression of human haptoglobin and rat α 2 -macroglobulin mRNA was induced. The induction of the acute phase response was dose- and time-dependent. In this study we demonstrate that CT-1, a novel cytokine belonging to the IL-6 cytokine family, is a hepatocyte stimulating factor.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-09-25 | FEBS Letters |