6533b82dfe1ef96bd1291330

RESEARCH PRODUCT

Paired pulse TMS over the right posterior parietal cortex modulates visuospatial perception

Antonio PalermoBrigida FierroMargherita FrancoliniSimona ScaliaGiuseppe GigliaFilippo Brighina

subject

AdultMaleposterior parietal cortexTime Factorsgenetic structuresPosterior parietal cortexStimulus (physiology)Settore BIO/09 - Fisiologiabehavioral disciplines and activitiesFunctional Lateralityvisuospatial perceptionParietal LobeHumansAttentionAnalysis of VarianceneglectSingle pulseHealthy subjectsCognitionTranscranial Magnetic StimulationNeurologyIntracortical facilitationVisuospatial perceptionSpace PerceptionRight posteriorSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyNeurosciencePPCPhotic Stimulationpsychological phenomena and processes

description

Abstract Objective We previously observed a relative contralateral neglect by right parietal single-pulse TMS given 150 ms after visual stimulus presentation. Here we investigated the effects of parietal paired TMS in normal subjects performing a visuospatial task. Methods Thirteen right-handed healthy subjects underwent a line-length judgement task during single-pulse and paired (1, 3, 5, 10 ms ISIs) TMS, delivered on the right parietal cortex 150 ms after visual stimulus. Results Single pulse TMS over the right parietal cortex induced a significant rightward bias compared to the baseline condition. At 1 and 3 ms ISIs, paired-pulse TMS did not show any effect in comparison with single pulse TMS. More importantly, 5 ms ISI was able to restore baseline levels, thus inducing a significant improvement of the performance compared to single-pulse TMS and 1–3 ms ISIs. Conclusions Paired TMS seems able to modulate activity of the right posterior parietal cortex in healthy subjects performing a cognitive visuospatial task.

yearjournalcountryeditionlanguage
2006-09-01Journal of the Neurological Sciences
https://doi.org/10.1016/j.jns.2006.04.006