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RESEARCH PRODUCT
Development, Differentiation, and Diversity of Innate Lymphoid Cells
Shigeo KoyasuAndreas DiefenbachMarco Colonnasubject
Transcription GeneticLymphocyteCellular differentiationImmunologyBiologyArticleTight Junctions03 medical and health sciencesMice0302 clinical medicinemedicineTranscriptional regulationCytotoxic T cellImmunology and AllergyAnimalsHumansCell Lineageskin and connective tissue diseases030304 developmental biologyRegulation of gene expression0303 health sciencesStem CellsInnate lymphoid cellCell DifferentiationT-Lymphocytes Helper-InducerImmunity InnateKiller Cells Naturalbody regionsMulticellular organismmedicine.anatomical_structureInfectious DiseasesGene Expression RegulationImmunologyCytokinesStem cell030215 immunologySignal Transductiondescription
Recent years have witnessed the discovery of an unprecedented complexity in innate lymphocyte lineages, now collectively referred to as innate lymphoid cells (ILCs). ILCs are preferentially located at barrier surfaces and are important for protection against pathogens and for the maintenance of organ homeostasis. Inappropriate activation of ILCs has been linked to the pathogenesis of inflammatory and autoimmune disorders. Recent evidence suggests that ILCs can be grouped into two separate lineages, cytotoxic ILCs represented by conventional natural killer (cNK) cells and cytokine-producing helper-like ILCs (i.e., ILC1s, ILC2s, ILC3s). We will focus here on current work in humans and mice that has identified core transcriptional circuitry required for the commitment of lymphoid progenitors to the ILC lineage. The striking similarities in transcriptional control of ILC and T cell lineages reveal important insights into the evolution of transcriptional programs required to protect multicellular organisms against infections and to fortify barrier surfaces.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-01 | Immunity |