6533b82dfe1ef96bd1291db3

RESEARCH PRODUCT

Evaluation of Sialic Acid in Infant Feeding: Contents and Bioavailability

Amparo AlegríaLorena ClaumarchirantEsther MatencioLuis Manuel Sanchez-silesMaría Jesús Lagarda

subject

AdultAdolescentBiological Availability01 natural sciencesYoung Adultchemistry.chemical_compound0404 agricultural biotechnologyLactationmedicineHumansFood scienceInfant feedingMilk Human010401 analytical chemistry04 agricultural and veterinary sciencesGeneral Chemistry040401 food scienceInfant FormulaN-Acetylneuraminic AcidBottle Feeding0104 chemical sciencesSialic acidBioavailabilityBreast Feedingmedicine.anatomical_structurechemistryColostrumFemaleNeuraminic AcidsGeneral Agricultural and Biological Sciences

description

Sialic acid (Sia) contents and bioaccessibility (BA) in human milk (HM) and infant formulas (IFs) were determined, and Sia intakes by infants between 0 and 6 months of age were evaluated. Total Sia contents in HM decreased during lactation from 136.14 to 24.47 mg/100 mL. The total Sia contents in IFs (13.15-25.78 mg/100 mL) were lower than in HM and were not related to the addition of ingredients acting as sources of Sia in their formulation. The Sia intakes derived from IF consumption were lower than in HM, and only one IF reached the intakes provided by HM from the age of 2 months. Despite the lower total Sia content in IFs, the BA of Sia in IFs (88.08-92.96%) was significantly greater than in mature HM (72.51%) and similar to that found in colostrum (96.43%). However, the Sia contents in the available soluble fraction of IFs did not reach those provided by HM.

yearjournalcountryeditionlanguage
2016-10-27Journal of Agricultural and Food Chemistry
https://doi.org/10.1021/acs.jafc.6b03273