6533b82dfe1ef96bd1291e07
RESEARCH PRODUCT
Histochemical localization of calcium ATPase in the cochlea of the guinea pig
M. BaggelmannW. J. MannJan Maurersubject
MaleATPaseGuinea PigsCalcium-Transporting ATPasesGuinea pigEndolymphHair Cells AuditorymedicineAnimalsInner earOrgan of CortiCochleabiologyHistocytochemistryGeneral MedicineBasolateral plasma membraneApical membraneCochleaCalcium ATPasemedicine.anatomical_structureOtorhinolaryngologyBiochemistryBiophysicsbiology.proteinFemaleCalcium Channelssense organsIntracellulardescription
The activity of Ca(2+)-ATPase in the inner ear of the guinea pig was studied ultracytochemically by the lead citrate reaction. The electron-dense reaction products as an expression of Ca(2+)-ATPase activity were localized in endolymphatic cells of Reissner's membrane, in outer and inner hair cells and in some supporting cells. The main finding was the difference in the localization of Ca(2+)-ATPase in outer and inner hair cells. In the latter cells the activity sites were mainly intracellular and in apical membrane specializations, whereas in the outer hair cells the enzyme was localized in the apical membrane specializations and the basolateral plasma membrane.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-05-01 | European Archives of Oto-Rhino-Laryngology |