6533b82dfe1ef96bd1291e64
RESEARCH PRODUCT
Evolutionary distances corrected for purifying selection and ancestral polymorphisms.
J A OteoGonzalo Oteo-garcíasubject
0301 basic medicineStatistics and ProbabilityTime FactorsADNModel parametersGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesNegative selection0302 clinical medicineQuantitative Biology::Populations and EvolutionStatistical physicsSelection GeneticMolecular clockPhylogenyMathematicsPolymorphism GeneticGeneral Immunology and MicrobiologyApplied MathematicsGeneral MedicineModels biològicsQuantitative Biology::GenomicsBiological EvolutionFormalism (philosophy of mathematics)030104 developmental biologyDimensional reductionModeling and SimulationMutationGeneral Agricultural and Biological Sciences030217 neurology & neurosurgeryEvolució (Biologia)description
Abstract Evolutionary distance formulas that take into account effects due to ancestral polymorphisms and purifying selection are obtained on the basis of the full solution of Jukes–Cantor and Kimura DNA substitution models. In the case of purifying selection two different methods are developed. It is shown that avoiding the dimensional reduction implicitly carried out in the conventional model solving is instrumental to incorporate the quoted effects into the formalism. The problem of estimating the numerical values of the model parameters, as well as those of the correction terms, is not addressed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | Journal of theoretical biology |