6533b82efe1ef96bd12926af

RESEARCH PRODUCT

Glucose, Lactate, and Ketone Body Utilization by Human Mammary Carcinomas in Vivo

K. WagnerK. H. BaesslerS. DavelP. VaupellF. Kallinowskil

subject

chemistry.chemical_classificationmedicine.medical_specialtyGlucose utilizationChemistryEndogenyIn vitroAmino acidLactic acidchemistry.chemical_compoundEndocrinologyBiochemistryIn vivoInternal medicinemedicineKetone bodiesGlucose breakdown

description

Uncontrolled growth, one of the fundamental properties of malignant tumors, requires a great supply of energy. This energy can be derived from the use of a variety of substrates. Besides glucose oxidation and glucose breakdown to lactic acid, the turnover of endogeneous substrates such as amino acids, free fatty acids and ketone bodies is well documented in vitro. However, under in vivo conditions, only glucose utilization has been investigated in detail, using tumor isotransplants in rodents. For human tumors, only scarce data is available, derived mainly from clinical observations rather than from systematic studies.

yearjournalcountryeditionlanguage
1985-01-01
https://doi.org/10.1007/978-1-4684-3291-6_77