Polyaspartamide-graft- Polymethacrylate Nanoparticles for Doxorubicin Delivery

6533b82efe1ef96bd12926ff

RESEARCH PRODUCT

Polyaspartamide-graft- Polymethacrylate Nanoparticles for Doxorubicin Delivery

Gennara Cavallaro Mauro Di Stefano Calogero Fiorica Mariano Licciardi Gaetano Giammona

subject

chemistry.chemical_classification Aqueous solution Polymers and Plastics Chemistry Carboxylic acid Nanoparticle Bioengineering Protonation Biomaterials Polymer chemistry Materials Chemistry Side chain Copolymer Drug carrier Cytotoxicity Biotechnology

description

A new PHEA-IB-PMANa + copolymer has been synthesized and its pH-induced self-assembly has been investigated in an aqueous medium. PHEA-IB-PMANa + formed nanoparticles with diameters from 25 to 50 nm upon protonation of the carboxylic acid moieties dislocated along the grafted polymethacrylate sodium salt side chains. The physico-chemical characterization of the nanoparticles was performed using light scattering, zeta-potential measurements, SEM, and AFM. Doxorubicin-loaded nanoparticles were prepared and drug release profiles were evaluated under conditions mimicking physiological media. A biological characterization was carried out by testing the cytotoxicity on Caco-2 cells, and cellular uptake on mouse monocyte macrophage (J774 A.1) and Caco-2 cells.

year	journal	country	edition	language
2011-01-21	Macromolecular Bioscience

https://doi.org/10.1002/mabi.201000399

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