6533b82efe1ef96bd12928f2

RESEARCH PRODUCT

Exhalation of ethylene oxide by rats on exposure to ethylene.

H.m. BoltJ.g. Filser

subject

Ethylene OxideMaleChromatographyEthyleneEthylene oxideRespirationReactive intermediateExhalationRats Inbred StrainsGeneral MedicineMetabolismEnvironmental exposureEnvironmental ExposureEthylenesRatschemistry.chemical_compoundchemistryBiotransformationBiochemistryAnimalsDesiccatorBiotransformation

description

Abstract When rats are exposed to ethylene in a closed desiccator jar chamber, the rate of metabolic elimination of the compound is influenced by pretreatment with Aroclor 1254 (metabolism increased) and diethyldithiocarbamate (metabolism inhibited). Biotransformation of ethylene leads to ethylene oxide as reactive intermediate. This is exhaled and can be quantitated in the gas phase of the system.

yearjournalcountryeditionlanguage
1983-04-01Mutation research
10.1016/0165-7992(83)90074-xhttps://pubmed.ncbi.nlm.nih.gov/6835263