6533b82efe1ef96bd1292925
RESEARCH PRODUCT
Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.
Hartmut JungKlaus PfizenmaierRoland Dr KurrleMartin RöllinghoffHermann Wagnersubject
Cytotoxicity ImmunologicvirusesImmunologychemical and pharmacologic phenomenaBiologyCross Reactionsmedicine.disease_causeEpitopeEpitopesMiceImmune systemAntigenIsoantibodiesGeneticsmedicineCytotoxic T cellAnimalsSimplexvirusCytotoxicityHistocompatibility Antigen H-2DMice Inbred BALB CH-2 AntigensVirologyCytolysisCTL*Herpes simplex virusImmunologyMice Inbred CBAT-Lymphocytes Cytotoxicdescription
Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-02-01 | Immunogenetics |