6533b82efe1ef96bd129313a

RESEARCH PRODUCT

Direct flow injection chemiluminescence determination of salicylamide

J. Martínez CalatayudL. Lahuerta ZamoraY Fuster Mestre

subject

Flow injection analysisDetection limitChromatographyCalibration curvePermanganateSalicylamidePharmaceutical formulationBiochemistryAnalytical Chemistrylaw.inventionchemistry.chemical_compoundPotassium permanganatechemistrylawmedicineEnvironmental ChemistrySpectroscopymedicine.drugChemiluminescence

description

Abstract A new direct flow injection chemiluminescence method is proposed for the determination of salicylamide, based upon the oxidation of the drug by potassium permanganate in dilute sulphuric acid. The calibration graph is linear over the range 20 ng ml−1 (30 limit of detection)–8 μg ml−1 salicylamide, with a relative standard deviation (n=50, 0.5 μg ml−1) of 1.7%. The average sample insertion rate is 142 h−1. The influence of relevant foreign compounds is found to be relatively slight. The method is applied to the determination of salicylamide in a pharmaceutical formulation and human urine.

yearjournalcountryeditionlanguage
1999-08-01Analytica Chimica Acta
https://doi.org/10.1016/s0003-2670(99)00290-1