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RESEARCH PRODUCT
Autophagy during ageing – from Dr Jekyll to Mr Hyde
Thomas WilhelmHolger Richlysubject
0301 basic medicineAgingmedia_common.quotation_subjectLongevityCellular homeostasisSaccharomyces cerevisiaeBiochemistry03 medical and health sciencesAutophagyAnimalsHumansCaenorhabditis elegansMolecular BiologyCaenorhabditis elegansmedia_commonbiologyAutophagyLongevityCell BiologyCatabolic Processbiology.organism_classificationCell biologyDrosophila melanogaster030104 developmental biologyAgeingSignal Transductiondescription
Autophagy is a ubiquitous catabolic process, which causes cellular bulk degradation through vesicular engulfment of obsolete, damaged or harmful cytoplasmic components. While autophagy regulates cellular homeostasis during development and in youth, there is mounting evidence that autophagy becomes increasingly dysfunctional with age. Recent work in Caenorhabditis elegans even suggests that late-life dysfunctional autophagy exhibits detrimental effects that drive the ageing process. Other studies link elevated autophagy closely to increased health and longevity. This review aims to put these apparently opposing views into perspective and define our current understanding of the role of autophagy during ageing.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-12-30 | The FEBS Journal |