6533b82efe1ef96bd1293326

RESEARCH PRODUCT

Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis

Paweł KafarskiPaweł KafarskiPiotr WieczorekŁUkasz BerlickiPaweł DżygielEwa RudzińskaArthur MuchaAnna Poliwoda

subject

aminophosphinatesaminophosphonatesOrganophosphonatescapillary electrophoresisElectrolyteBiochemistryAnalytical ChemistryInclusion compoundchemistry.chemical_compoundCapillary electrophoresisOrganic chemistrychemistry.chemical_classificationChromatographycyclodextrinsMolecular StructureCyclodextrinChemistryOrganic ChemistryenantiodiscriminationElectrophoresis CapillaryReproducibility of ResultsEstersStereoisomerismGeneral MedicineHydrogen-Ion ConcentrationPhosphinic AcidsPhosphinic AcidsPhase compositionEnantiomer

description

Capillary electrophoresis was successfully applied for separation of the enantiomers of N-benzyloxycarbonyl-alpha-aminophosphonic and alpha-aminophosphinic acids as well as their ethyl and phenyl monoesters with the use of a range of commercially available cyclodextrins (alpha, beta and hydroxypropyl-gamma-cyclodextrins) as chiral selectors. The dependence of effectiveness of separation on type and concentration of these chiral selectors as well as on pH of background electrolyte was examined in some detail.

yearjournalcountryeditionlanguage
2005-12-07Journal of Chromatography A
10.1016/j.chroma.2006.10.065https://doi.org/10.1016/j.chroma.2006.10.065