6533b82efe1ef96bd1293ae7

RESEARCH PRODUCT

ChemInform Abstract: LEAD TETRAACETATE OXIDATION OF PHENYLHYDRAZONES OF 3-BENZOYLAZOLES. SYNTHESIS OF AZOACETATES AND THEIR CONVERSION INTO INDAZOLES

Vincenzo FrennaNicolò VivonaSilvestre BuscemiMichele Condò

subject

chemistry.chemical_classificationchemistry.chemical_compoundAzo compoundAluminium chloridechemistryBicyclic moleculemedicineOrganic chemistryHydrazoneGeneral MedicineBenzeneMedicinal chemistrymedicine.drug

description

Lead tetraacetate (LTA) oxidation of (E)- and (Z)-phenylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole, 3-benzoyl-5-phenylisoxazole, and 3-benzoyl-4-methyl-1,2,5-oxadiazole has been studied. Conversion of azoacetate products into 3-(azol-3-yl)-substituted indazoles has been achieved by reacting them with aluminium chloride in benzene at room temperature.

https://doi.org/10.1002/chin.198530221