6533b82efe1ef96bd1293e3a

RESEARCH PRODUCT

Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study

Montserrat Ruiz-garcíaH. Schwarz-chavarriJavier Díez-domingoVicente Francisco Gil-guillénSilvia Perez-vilarConcepción Carratalá-munueraA. Belenguer-vareaAlberto Arnedo-penaJ.l. Micó-esparzaJoan Puig-barberà

subject

AdultMalemedicine.medical_specialtyAdolescentInfluenza vaccineCase-control studiesArticleSeasonal influenzaYoung AdultInfluenza Human/epidemiologyInternal medicineInfluenza HumanMedicineHumansProspective StudiesYoung adultProspective cohort studyIntensive care medicineReverse transcriptase polymerase chain reactionAgedHospitalizationsGeneral VeterinaryGeneral Immunology and Microbiologybusiness.industryCase comparisonVaccinationPublic Health Environmental and Occupational HealthCase-control studyvirus diseasesMiddle AgedConfidence intervalVaccinationHospitalizationInfectious DiseasesInfluenza vaccinesRisk factorsVaccines InactivatedSpainMolecular MedicineFemalebusinessRespiratory syncytial virus infections/epidemiology

description

Highlights ► We perform a case–case comparison as an improvement of the test-negative design. ► We report IVE estimates with a low probability of bias. ► Influenza vaccination halved the risk of confirmed influenza hospitalization. ► This effect was consistent regardless of age over 60. ► The measured effect was specific for confirmed influenza hospitalizations.

yearjournalcountryeditionlanguage
2012-07-01Vaccine
10.1016/j.vaccine.2012.07.006http://europepmc.org/articles/PMC7115682