6533b82efe1ef96bd1293e5a
RESEARCH PRODUCT
The effect of the calibre and length of needle on the stability of sclerosing foam.
Marian SimkaJacek HobotMarcin SkułaJoanna Czajasubject
medicine.medical_specialtybusiness.industrySodiumPolidocanolchemistry.chemical_elementGeneral Medicine030204 cardiovascular system & hematologyGastroenterologySclerosing SolutionsPolyethylene GlycolsPolidocanolSodium Tetradecyl Sulfate030207 dermatology & venereal diseases03 medical and health sciencesFoam sclerotherapy; adverse events; needles0302 clinical medicinechemistryNeedlesInternal medicineSclerotherapymedicineHumansCardiology and Cardiovascular Medicinebusinessmedicine.drugdescription
Objectives Little is known how calibre and length of needles affect the stability of sclerosing foam. Methods Foams were made of 0.5%, 1%, 2% and 3% polidocanol, and 0.2%, 0.5%, 1% and 3% sodium tetradecyl sulfate (STS), which were mixed with air in the proportion of 4:1. These foams were ejected through needles with the length of: 4 mm, 6 mm and 13 mm, and diameter of: 0.26 mm, 0.3 mm and 0.4 mm. Results Foams made of more concentrated polidocanol were more stable. Regarding STS an opposite relationship was revealed. Foams made of polidocanol were more stable if ejected through a longer needle, while the length of needle did not significantly affect stability of STS foams. Foams ejected through 0.26 mm diameter needles were very unstable. In the case of 0.5% polidocanol, 0.3x6mm needle provided atypically stable foam. Conclusion In order to inject maximally stable foam, calibre and length of needle should be taken into account.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-11-26 | Phlebology |