6533b82efe1ef96bd1294581
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of New Bis(tetrahydropyrrolo[3,4-b]carbazoles) with a Functionalized Diaryl Spacer.
Ulf PindurFarokh Mehrabanisubject
chemistry.chemical_compoundChemistrySuccinic acidSpermineGeneral MedicineCombinatorial chemistryLinkerDNAdescription
Some new bis(tetrahydropyrrolo[3,4-b]carbazoles) were synthesized by Diels–Alder reactions of in-situ generated indole-2,3-quinodimethanes with a variety of bismaleimides as dienophiles and also by reaction of dianilines with a succinic acid anhydride group incorporated into a biscarbazole. In a special reaction a spermine linker was introduced. The new biscarbazoles represent potential DNA ligands for the development of new antitumor active drugs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-24 | ChemInform |