6533b82ffe1ef96bd12947a9

RESEARCH PRODUCT

Synthesis of a new family of bi- and polycyclic compounds via Pd-catalyzed amination of 1,7-di(3-bromobenzyl)cyclen

Franck DenatIrina P. BeletskayaAlexei K. BuryakRoger GuilardAlexei D. AverinAnton V. Shukhaev

subject

TrisCryptand010402 general chemistry01 natural sciencesBiochemistryMedicinal chemistrycyclenCatalysischemistry.chemical_compoundCyclen[ CHIM.ORGA ] Chemical Sciences/Organic chemistryDrug DiscoveryOrganic chemistryComputingMilieux_MISCELLANEOUSAminationPd-catalyzed aminationBicyclic molecule[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryOrganic Chemistrybicyclic cryptand0104 chemical scienceschemistryIntramolecular forcefunctionalizationPolyamine

description

Abstract New bicyclic cryptand type compounds are synthesized by reacting 1,7-di(3-bromobenzyl)cyclen with 1 equiv of linear polyamines under dilute conditions using Pd-catalyzed amination. Bis(cyclen) and tris(cyclen) compounds containing linear polyamine linkers between benzylated cyclens are obtained by a similar procedure using different reaction conditions. Cyclization of these species via intramolecular catalytic diamination led to tri- and tetracyclic polyaza compounds.

yearjournalcountryeditionlanguage
2008-06-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2008.04.045