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RESEARCH PRODUCT
Validation of (68)Ge/(68)Ga generator processing by chemical purification for routine clinical application of (68)Ga-DOTATOC.
Giovanni De PietriRoberto SghedoniFrank RoeschElisa GrassiFederica FioroniDiana SalvoAnnibale VersariAlessandro FraternaliMattia Astisubject
Cancer ResearchGenerator (computer programming)ChromatographyElutionIon chromatographyGallium RadioisotopesMass spectrometryOctreotide68ga dotatocchemistry.chemical_compoundchemistryYield (chemistry)Isotope LabelingPositron-Emission TomographyAcetoneOrganometallic CompoundsMolecular MedicineRadiology Nuclear Medicine and imagingPurification methodsClinical MedicineRadiopharmaceuticalsdescription
Abstract Introduction Imaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68 Ga-DOTATOC and PET/CT. Methods In this work, a purification method for the 68 Ge/ 68 Ga generator eluate and a method to produce 68 Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68 Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry. Results 68 Ga-DOTATOC preparations ( n =33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution. Conclusions 68 Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-01 | Nuclear medicine and biology |