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RESEARCH PRODUCT

Mechanistic studies of the ring opening reactions of [1,2,3]triazolo[1,5-a]pyridines

Gurnos JonesBelén AbarcaJaume VecianaGemma RodrigoJosé Vidal-gancedoRafael Ballesteros

subject

chemistry.chemical_compoundChemistryStereochemistryOrganic ChemistryDrug DiscoveryTriazoleRing (chemistry)Biochemistry

description

Abstract A mechanism with radical intervention is proposed for the opening of the triazole ring in [1,2,3] triazolo[1,5-a]pyridines which results in the production of 2- or 2,6-disubstituted pyridines.

https://doi.org/10.1016/s0040-4020(98)00532-8