6533b82ffe1ef96bd1294f2e
RESEARCH PRODUCT
false
subject
0301 basic medicineMultidisciplinaryChemistryVesicleMolecular neuroscienceHippocampal formationTransmembrane proteinCell biology03 medical and health sciences030104 developmental biology0302 clinical medicineMembranePremovement neuronal activityReceptorCytoskeleton030217 neurology & neurosurgerydescription
Summary Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | iScience |