6533b82ffe1ef96bd129501e
RESEARCH PRODUCT
Determination of the technetium-99m mercaptoacetyltriglycine plasma clearance in children by means of a single blood sample: a multicentre study
R. SixtJ. KolinskaAmnon PiepszJ. KotzerkeKlaus HahnIsky Gordonsubject
Body surface areaTechnetium-99m-MercaptoacetyltriglycinePlasma clearancebusiness.industrySample (material)Renal functionGeneral MedicinePharmacokineticsBlood plasmaMedicineRadiology Nuclear Medicine and imagingbusinessNuclear medicineClearancedescription
A multicentre European study was undertaken in order to determine a reasonable algorithm allowing the determination of overall technetium-99m mercaptoacetyltriglycine clearance using a single blood sample. Employing multiple blood sample clearance as a reference method, it was shown that an acceptable estimation of the MAG3 renal clearance could be obtained using a blood sample taken at any time between 30 and 40 min after tracer injection. After correction for body surface area, comparison of clearance determined using (a) the single blood sample and (b) the multiple blood samples provided a coefficient of correlation of 0.949 and an SEE of 27 ml/min. This algorithm is valid for clearance values higher than 100 ml/min/1.73 m2 and for children older than 1 year of age.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-03-01 | European Journal of Nuclear Medicine |