‘One-Pot’ Synthesis of Raumacline from Ajmaline

6533b82ffe1ef96bd1295a0a

RESEARCH PRODUCT

‘One-Pot’ Synthesis of Raumacline from Ajmaline

subject

Chemistry Alkaloid Organic Chemistry One-pot synthesis Riboflavin Biochemistry Catalysis Inorganic Chemistry chemistry.chemical_compound Ajmaline Raumacline Biotransformation Yield (chemistry)Drug Discovery medicine Hemiacetal Organic chemistry Physical and Theoretical Chemistry medicine.drug

description

For the alkaloid raumacline (2), which is a biotransformation product of ajmaline (1) in Rauwolfia serpentina cell cultures, an efficient ‘one-pot’ synthesis was developed using a NaBH4/riboflavin/light-mediated transformation of 1 into 2 with a total yield of 86%.

year	journal	country	edition	language
1993-11-03	Helvetica Chimica Acta

https://doi.org/10.1002/hlca.19930760713

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