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RESEARCH PRODUCT

Phorbol Esters and Muscarinic Receptor Agonists Activate Phospholipase D in Heart and Brain

T. HollerR. LindmarKonrad Löffelholz

subject

chemistry.chemical_compoundchemistryBiochemistryPhospholipase DMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M3lipids (amino acids peptides and proteins)Muscarinic acetylcholine receptor M2PhosphatidylethanolPhosphatidic acidMuscarinic acetylcholine receptor M1Protein kinase C

description

Phospholipase D (PLD) hydrolyzes phosphatidylcholine and thereby seems to play a key role in a novel pathway of signal transduction. PLD activity in rat hippocampal slices and atria of rat, guinea pig and chicken hearts was determined by measuring the catalytic products choline (Ch), phosphatidic acid (PA) and, in the presence of a primary alcohol, phosphatidylpropanol or phosphatidylethanol. It was found that the PLD activity was high, even under resting conditions, in both tissues, especially in the hippocampus, and that the enzyme activity could be enhanced by activation of protein kinase C and by muscarinic receptor stimulation.

yearjournalcountryeditionlanguage
1991-01-01
https://doi.org/10.1007/978-3-642-75136-3_31