Motoro funkciju novērtēšana rotarod un kondziela testos pelēs išēmiska insulta modelī

6533b82ffe1ef96bd1296034

RESEARCH PRODUCT

Motoro funkciju novērtēšana rotarod un kondziela testos pelēs išēmiska insulta modelī

Evita Islamgarajeva

subject

motorās funkcijas Farmācija fVCAo peles rotarod tests kondziela tests

description

Išēmisks insults ir viens no biežākajiem nāves un invaliditātes cēloņiem pasaulē. Rezultātā tiek būtiski bojāti smadzeņu rajoni, kas izraisa motoros traucējumus. Lai izprastu išēmiska smadzeņu bojājuma izraisītās motorās komplikācijas cilvēkiem, pielieto preklīniskos uzvedības testus izmēģinājuma dzīvniekiem. Maģistra darba mērķis bija, izmantojot preklīnisku insulta modeli, izpētīt muskuļu koordinācijas un muskuļu spēka izmaiņas pelēm, pielietojot kondziela un rotarod testus, divu mēnešu periodā. Pētījuma rezultāti parāda, ka kondziela tests išēmijas pelēm parādīja jutīgumu agrīna muskuļu spēka vājuma identifikācijā, savukārt rotarod tests neuzrādīja izmaiņas muskuļu koordinācijā, sākot ar piekto dienu pēc insulta. Kondziela testam ir nepieciešami tālāki pētījumi, lai uzkrātie dati ļautu zinātniekiem izvēlēties pēc iespējas jutīgākus uzvedības testus.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59748

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