Ogļskābes anhidrāžu II un IX izoformu strukturālie pētījumi specifisku inhibitoru dizainam

6533b82ffe1ef96bd129603c

RESEARCH PRODUCT

Ogļskābes anhidrāžu II un IX izoformu strukturālie pētījumi specifisku inhibitoru dizainam

subject

racionālais zāļu dizains CA IX CA II proteīnu rentgenstruktūranalīze ogļskābes anhidrāze Bioloģija

description

Darba mērķis bija ar proteīnu kristalogrāfijas palīdzību noskaidrot dažādu inhibitoru novietojumus zīdītājos sastopamo ogļskābes anhidrāžu II un IX izoformu aktīvajos centros nolūkā radīt jaunu ārstniecības vielu prototipus. Maģistra darba tapšanas laikā tika iegūtas vairākas ogļskābes anhidrāžu II un IX izoformu proteīnu struktūras kompleksā ar dažādiem savienojumiem. Iegūtie rezultāti ir izmantojami racionālam zāļu dizainam, ar mērķi izveidot selektīvus ar audzējiem saistītās ogļskābes anhidrāzes IX, vai ar glaukomu saistītās II izoformas inhibitorus. Maģistra darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā, proteīnu kristalogrāfijas laboratorijā Dr. biol. Kaspara Tāra vadībā.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/29477

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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  - PE2_2 Phenomenology of fundamental interactions
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  - PE2_16Non-linear physics
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SHSocial Sciences and Humanities
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