6533b82ffe1ef96bd1296208
RESEARCH PRODUCT
Role of intestinal epithelial CD36 in obesity and endotoxemia driven by lipid absorption
Sarah Moreira Milheirosubject
[SDV.SA] Life Sciences [q-bio]/Agricultural sciencesLipidesGutObesityObesitéEndotoxémieCd36LipidsIntestinAbsorptionEndotoxemydescription
Intestinal dysbiosis, increased permeability and inflammation are the hallmarks in obese patients, highlighting the role of small intestine beyond providing with calories. CD36 is a ubiquitous scavenger receptor that exhibits high binding affinity for long-chain fatty acids and is highly expressed in enterocytes, endothelial and immune cells. Interestingly, CD36-/- mice and humans with CD36 polymorphisms have an impaired synthesis of triglyceride-rich lipoprotein (TRL). To evaluate the role of CD36 expressed by intestinal-epithelial cells (IEC) in obesity, we conducted experiments on male and female mice deleted in CD36 in IEC (ENT-KO) and control mice (ENT-FL), under standard and high-fat diet conditions. We showed that ENT-KO mice are more sensitive to diet-induced obesity. This phenomenon was associated with impaired synthesis of TRL, enhanced endotoxemia, intestinal permeability, and alterations in gut microbiota throughout lipid absorption. The present study highlights that CD36 of IEC is a key player in obesity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |