6533b830fe1ef96bd129661b
RESEARCH PRODUCT
Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
Lionel ApetohLionel ApetohAmit AwasthiCaroline PotVijay K. Kuchroosubject
Interleukins/immunologyImmunologyInterleukin-10/biosynthesis/immunologyT-Lymphocytes Regulatory/immunologyddc:616.07T-Lymphocytes RegulatoryArticleAutoimmune Diseases03 medical and health sciences0302 clinical medicineImmunology and AllergyCytotoxic T cellTh17 Cells/immunologyAnimalsHumansIL-2 receptorSTAT3STAT4030304 developmental biology0303 health sciencesbiologyZAP70InterleukinsFOXP33. Good healthCell biologyddc:616.8Interleukin-10Interleukin 10Autoimmune Diseases/immunologyImmunologyInterleukin 12biology.proteinTh17 Cells030215 immunologydescription
Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-12-01 |